Research progress about the effect of gut microbiome on the formation process of calcium oxalate stone through gut-kidney axis
10.3760/cma.j.cn112330-20210324-00149
- VernacularTitle:肠道菌群在肠-肾轴中对草酸钙结石形成影响的研究进展
- Author:
Sihao CHEN
1
;
Min LEI
;
Nanxi LI
;
Xinguo HUANG
;
Shiqi CHEN
;
Wenhao HUANG
;
Lingyue AN
;
Shujue LI
;
Wenqi WU
Author Information
1. 广州医科大学附属第二医院泌尿外科，广州 510260
- Keywords:
Kidney calculi;
Calcium oxalate;
Gut Microbiome;
Gut-kidney axis;
Treatment
- From:
Chinese Journal of Urology
2022;43(9):713-716
- CountryChina
- Language:Chinese
-
Abstract:
Calcium oxalate (CaOx) stone is the main type, and its formation is closely related to the metabolism of oxalic acid and calcium. Gut Microbiome is normal microflora which settled in the human intestinal tract and plays an important role in regulating a variety of metabolism in the body. In the past, Oxalobacter formigenes in gut was a protective factor for the formation of CaOx stones. Recently, it has been found that the bacteria regulating oxalate metabolism were not limited to Oxalobacter formigenes. Gut Microbiome of CaOx stones formers is different from healthy people. It regulates the metabolism of oxalic acid in the body through the gut-kidney axis and affect the formation of CaOx stone. The purpose of this study is to describe the characteristics of intestinal flora in patients with CaOx stones, and to summarize its potential function in the formation of CaOx stones and its possible clinical application in the future.
