Diagnosis and treatment of genetically related urinary calculi
10.3760/cma.j.cn112330-20210721-00387
- VernacularTitle:遗传相关性泌尿系结石诊治的研究进展
- Author:
Wenzhao ZHANG
1
;
Longhui LAI
;
Peide BAI
;
Tao WANG
;
Anran SUN
;
Yu LUO
;
Kai ZHU
;
Jinchun XING
;
Zhangqun YE
;
Bin CHEN
Author Information
1. 厦门大学附属第一医院泌尿外科，厦门 361001
- Keywords:
Kidney calculi;
Whole-genome analysis;
Single gene mutation
- From:
Chinese Journal of Urology
2022;43(6):477-480
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of single-gene nephrolithiasis has been increasing year by year. With the application of whole-genome analysis and whole-exome sequencing technology, the etiology of single-gene mutations leading to the development of urinary calculi has been extensively verified. Therefore, this article reviews the research on urinary calculi-related genetic diseases at home and abroad, and introduces transport proteins and channels; ions, protons and amino acids. The role of urinary calculi in the majority of clinicians realizes the significance of genetic testing in such diseases, thereby increasing the understanding of genetically related urinary calculi and improving the level of clinical diagnosis and treatment.
