Research advances of urinary cell-free DNA in the detection and therapy of bladder cancer
10.3760/cma.j.cn112330-20220113-00023
- VernacularTitle:尿游离DNA在膀胱癌诊治中应用的研究进展
- Author:
Jinze LI
1
;
Dehong CAO
;
Yin HUANG
;
Tianhai LIN
;
Qiao XIONG
;
Daqing TAN
;
Jianzhong AI
;
Liangren LIU
;
Qiang WEI
Author Information
1. 四川大学华西医院泌尿外科，成都 610041
- Keywords:
Urinary bladder neoplasms;
Bladder cancer;
Cell-free DNA;
Diagnosis;
Prognosis;
Biomarkers
- From:
Chinese Journal of Urology
2022;43(6):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is a common malignancy in the genitourinary system and the current therapeutic approaches are unsatisfactory. Urinary cell-free DNA (ucf DNA) has the ability to give comprehensive and crucial information on cancer as it carries genetic messages from cells shedding directly into urine as well as transporting from circulation. The ucf DNA of patients with bladder cancer carries disease information, suggesting that ucf DNA may have the ability to detect, monitor, and prognosticate patients with bladder cancer. The ucf DNA analysis bridges the gap between current techniques and enhances diagnostic and detection capabilities, and has a very promising future in term of translation into clinical practice. This article reviewed the progress of clinical applications of ucf DNA in bladder cancer.
