Pathogenesis, prevention and treatment of acute kidney injury in elderly patients with COVID-19

VernacularTitle:老年新型冠状病毒肺炎患者并发急性肾损伤的发病机制及防治
Author: Huiping KONG ¹ ; Mengqing MA ; Xin WAN ; Changchun CAO
Author Information

1. 南京医科大学附属逸夫医院肾脏内科，南京　211166
Keywords: COVID-19; Acute kidney injury; Pathogenesis; Prevention and therapy
From: Chinese Journal of Geriatrics 2022;41(11):1394-1399
CountryChina
Language:Chinese
Abstract: With the coronavirus disease 2019(COVID-19)pandemic across the world, numerous variants have emerged.As a high-risk group for COVID-19, the elderly are prone to acute kidney injury(AKI), with atypical clinical features and high proportions of patients with critical illness.Its pathogenesis mainly includes direct damage to the kidney via the angiotensin-converting enzyme 2(ACE2)pathway, the extracellular matrix metalloproteinase inducer(CD147)pathway, and age-related renal dysfunction, inflammatory aging, immune aging and other non-specific mechanisms, which significantly increase the risk of adverse prognosis.Therefore, the establishment of an early warning system for AKI, increasing vaccination coverage, nutritional support, treatment of primary diseases, extracorporeal supportive therapy and other control measures are particularly important to prognosis improvement.This review summarized the pathogenesis, early prevention and treatment of AKI in elderly patients with COVID-19.