Advances in the understanding of clonal hematopoiesis in cardiovascular disease
10.3760/cma.j.issn.0254-9026.2022.10.022
- VernacularTitle:克隆性造血在心血管疾病中的认识和研究进展
- Author:
Yuekai SHI
1
;
Rende XU
;
Jianying MA
;
Junbo GE
Author Information
1. 复旦大学附属中山医院心内科 上海市心血管病研究所 国家放射与治疗临床医学研究中心，上海 200032
- Keywords:
Clonal, organism;
Cardiovascular disease;
Hematopoietic stem cells
- From:
Chinese Journal of Geriatrics
2022;41(10):1244-1248
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is a leading cause of death among the elderly and the incidence of coronary artery disease progressively increases with advancing age.Traditional risk factors are incompletely predictive of cardiovascular disease development.With the advent of high-throughput next-generation genome sequencing technologies in recent years, some studies have indicated that aging is associated with an increased frequency of somatic mutations of hematological neoplasm-related genes in the hematopoietic system, providing a competitive growth advantage for mutant hematopoietic cells and thus allowing for their clonal expansion, a phenomenon known as clonal hematopoiesis of indeterminate potential(CHIP). CHIP is common in middle-aged and elderly populations and is associated with increased risks of hematological cancer and all-cause death.There is growing evidence that CHIP is involved in the development and progression of multiple cardiovascular disorders through the activation of inflammatory responses.In this review, we will give an overview of current advances in the understanding of clonal hematopoiesis in cardiovascular disease.
