Mental illness and risk of developing obstructive sleep apnea: a two-sample Mendelian randomization study
10.3760/cma.j.issn.0254-9026.2022.10.003
- VernacularTitle:双样本孟德尔随机化研究精神疾病和阻塞性睡眠呼吸暂停的关系
- Author:
Yuxing LIU
1
;
Yuyang MIAO
;
Minghui ZHAO
;
Qiang ZHANG
Author Information
1. 天津医科大学总医院保健医疗部 天津市老年病学研究所，天津 300052
- Keywords:
Sleep apnea, obstructive;
Bipolar disorder;
Depressive disorder;
Mendelian randomization
- From:
Chinese Journal of Geriatrics
2022;41(10):1146-1149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:A two-sample Mendelian randomized study was used to investigate the relationship between psychiatric disorders and the risk of developing obstructive sleep apnea(OSA).Methods:Genetic variations in bipolar disorder, depression, Alzheimer's disease and schizophrenia were used as instrumental variables and data from genome-wide association studies of OSA patients from the Finngen Consortium were used.In this study, inverse variance weighted method was used as the main analysis method, and three sensitivity analyses including weighted median analysis, MR-Egger regression analysis and MR-PRESSO analysis were jointly applied.Results:Higher genetic predisposition for depression and bipolar disorder increased the risk of developing OSA, the odds ratio is 1.18(95% CI: 1.02-1.37, P=0.026)and 1.06(95% CI: 1.01-1.12, P=0.038)for each unit increase with log-transformed odds ratios of depression and bipolar disorder, respectively.Genetic susceptibility to Alzheimer's disease and schizophrenia was not associated with the risk of developing OSA. Conclusions:This study suggests that a higher genetic predisposition for depression and bipolar disorder may lead to a higher risk of developing OSA.OSA and psychiatric disorders such as depression and bipolar disorder have a high incidence in the elderly, however, their causal effects still need to be studied.
