Clinical characteristics and prognosis of severe coronal virus disease 2019 pneumonia combined with coronary artery disease in the elderly
10.3760/cma.j.issn.0254-9026.2022.08.013
- VernacularTitle:老年重症新型冠状病毒肺炎合并冠心病患者的临床特点和预后
- Author:
Ruijin XU
1
;
Ge LIU
;
Yuying SU
;
Juan CHEN
;
Yunjie GE
;
Junjie GAO
;
Liu LIU
Author Information
1. 青岛市市立医院干部保健科，青岛 266071
- Keywords:
Aged;
Coronal virus disease 2019 pneumonia;
Coronary disease;
Inflammation
- From:
Chinese Journal of Geriatrics
2022;41(8):961-964
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical manifestations and prognosis of severe coronal virus disease 2019(COVID-19)pneumonia combined with coronary artery disease(CAD)in the elderly.Methods:A total of 351 old patients(≥60 years)with severe COVID-19 pneumonia combined with CAD admitted to Tongji Hospital of Wuhan from February 2020 to March 2020 were enrolled in this retrospective study.The patients were divided into CAD group(n=52)and non-CAD group(n=299). The clinical data, the changes of blood tests and cardiovascular complications were observed.Results:Compared with non-CAD group, CAD group showed a longer time of stay in hospital[(12.3±2.6)d and(9.3±2.1)d, t=3.24, P=0.002], and higher incidence of cardiovascular complications, such as myocardial infarction(7.7% and 0.0%, χ2=21.6, P<0.001), heart failure(15.4% and 0.3%, χ2=34.7, P<0.001), arrhythmia(50.0% and 12.4%, χ2=24.45, P<0.001)and all-cause mortality(15.4% and 4.3%, χ2=7.94, P=0.005). The serum levels of interleukin-2 receptor, interleukin 6, CK-MB, cTnI, NT-proBNP, D-dimer and fibrinogen were higher in CAD group than in non-CAD group.The oxygenation index was significantly lower and the blood lactic acid level was higher in CAD group than in non-CAD group. Conclusions:The aged patients with severe COVID-19 pneumonia combined with CAD show obvious inflammatory reaction, high incidence of cardiovascular complications and high mortality.
