Metabolic significance of non-alcoholic fatty liver disease in non-obese adults.
- Author:
Kwang Eun LEE
1
;
Yoo Mee KIM
;
Eun Seok KANG
;
Hae Jin KIM
;
Hae Won CHUNG
;
Si Hoon LEE
;
Hyeung Jin KIM
;
Dae Jung KIM
;
Soo Kyung KIM
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Hyun Chul LEE
;
Kap Bum HUH
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. kjh1212@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Non-alcoholic fatty liver disease;
Body mass index;
Metabolic syndrome;
Central obesity
- MeSH:
Adipose Tissue;
Adult*;
Blood Glucose;
Body Mass Index;
Cholesterol;
Diabetes Mellitus;
Dyslipidemias;
Fasting;
Fatty Liver*;
Female;
Health Promotion;
Hepatitis B;
Humans;
Insulin;
Insulin Resistance;
Liver;
Male;
Obesity;
Obesity, Abdominal;
Physical Examination;
Proinsulin;
Ultrasonography;
Waist Circumference;
Waist-Hip Ratio
- From:Korean Journal of Medicine
2002;63(5):488-495
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It is well known that non-alcoholic fatty liver disease is associated with metabolic syndrome such as obesity, type II diabetes mellitus, dyslipidemia. Non-alcoholic fatty liver disease is frequently found in non-obese adults, but the meaning of it is unknown. So we studied the association of non-alcoholic fatty liver disease in non-obese adults and metabolic abnormalities. METHODS: We examined 779 Korean adults above 30 years old (274 men, 505 women) participating in medical check-up in Health Promotion Center. Hepatitis B and C serologies were negative, and average weekly alcohol intake was or=25 kg/m2, n=348) group (65.5 vs 32.3%, p<0.05). Compared with obese group, waist circumference, waist hip ratio, body fat, impaired fasting serum glucose, total cholesterol, HDL-cholesterol, total cholesterol to HDL-cholesterol ratio, fasting insulin, proinsulin, HOMA-IR and HOMA-beta were significantly different in non-obese, non-alcoholic fatty liver group. After multiple regression analysis, waist circumference was associated with non-alcoholic fatty liver disease in non-obese individuals. Odd ratios of insulin resistance in non-obese, non-alcoholic fatty liver group were 5.8 (CI: 3.1~10.9). CONCLUSION: The frequency of non-alcoholic fatty liver disease was very high in non-obese adults and well associated with central obesity and insulin resistance.
