Effect of Risedronate on fracture healing in elderly patients with osteoporotic femoral intertrochanteric fracture
10.3760/cma.j.issn.0254-9026.2022.07.005
- VernacularTitle:利赛膦酸钠对老年骨质疏松性股骨转子间骨折患者骨折愈合的影响
- Author:
Lele LIAO
1
;
Zhanghuan YANG
;
Jiangdong NI
;
Guangxu HE
Author Information
1. 中南大学湘雅二医院骨科，长沙 410011
- Keywords:
Osteoporosis;
Phosphonic acids;
Femoral fractures;
Fracture healing
- From:
Chinese Journal of Geriatrics
2022;41(7):772-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Risedronate on fracture healing in elderly patients with osteoporotic femoral intertrochanteric fracture.Methods:A retrospective case-control study was conducted on elderly patients with osteoporotic femoral intertrochanteric fractures in our hospital from June 2019 to June 2020.They were followed up regularly for 1 year after proximal femoral nail anti-rotation(PFNA)internal fixation.According to whether the patients took Risedronate during hospitalization, the patients were divided into two groups(PFNA internal fixation combined with Risedronate, 39 cases)and control group(PFNA internal fixation alone, 44 cases). The BMD values before and 1 year after operation were compared between the two groups.Harris score was used to evaluate hip function, Rush score was used to evaluate fracture healing, and the operation-related complications, adverse drug reactions and fractures in other parts were recorded.Results:The fractures of all patients healed 12 months after operation.There were no recurrent fractures in both groups during follow-up.The mean bone mineral density(BMD)T value in healthy side hip was(-2.83±0.46)in Risedronate group and(-3.16±0.42)in control group( t=-3.397, P=0.001). Among the total 83 patients, 39 patients in the Risedronate group had no obvious adverse reactions; 1 patient of 44 patients in the control group had obvious upper abdominal pain and discomfort, accompanied by nausea and lack of appetite.These symptoms improved after stopping the drug. Conclusions:Risedronate taken early after surgery does not affect fracture healing and can improve bone mineral density of healthy side hip.
