Exosomes' roles in the pathogenesis of Alzheimer's disease and the diagnostic and therapeutic values

VernacularTitle:外泌体在阿尔茨海默病发病中的作用及其诊疗价值
Author: Xueying LIU ¹ ; Renjun LYU ; Qingqing YIN ; Xunyao HOU ; Xueping LIU
Author Information

1. 山东第一医科大学附属省立医院，济南　250021
Keywords: Exosomes; Alzheimer's disease; Amyloid beta
From: Chinese Journal of Geriatrics 2022;41(6):734-738
CountryChina
Language:Chinese
Abstract: Exosomes are nanoscal-scale vesicles containing a variety of proteins(HSP70, actin, Alix, etc.), lipids, mRNAs and miRNAs.They are commonly found in various tissues and cells of the organism.They are involved in processes such as intercellular communication, immune regulation and cell signaling pathway regulation, and then play an important role.Recent studies have shown that exosome-mediated intercellular signaling plays an important role in the progression of Alzheimer's disease(AD). This paper reviewed the general characteristics of exosomes, clarifies the possible role of exosomes in the pathogenesis of AD, and also discussed the application prospect and the related challenges of exosomes as a new potential option in the future treatment of AD.