The prognostic significance of peripheral monocytosis on admission in patients with acute myocardial infarction.
- Author:
Young Joon HONG
1
;
Myung Ho JEONG
;
Seung Hyun LEE
;
Ok Young PARK
;
Woo Seok PARK
;
Ju Han KIM
;
Weon KIM
;
Jay Young RHEW
;
Seung Ho YANG
;
Young Keun AHN
;
Jeong Gwan CHO
;
Soon Pal SUH
;
Byoung Hee AHN
;
Jong Chun PARK
;
Sang Hyung KIM
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Coronary Diseases;
Myocardial Infarction;
Angioplasty;
Inflammation
- MeSH:
Angioplasty;
C-Reactive Protein;
Coronary Disease;
Disease-Free Survival;
Follow-Up Studies;
Hospitalization;
Humans;
Incidence;
Inflammation;
Jeollanam-do;
Male;
Monocytes;
Myocardial Infarction*;
Percutaneous Coronary Intervention;
Prognosis;
Troponin I;
Troponin T
- From:Korean Journal of Medicine
2002;63(5):521-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The inflammation is an important feature of atherosclerotic lesions, and peripheral monocytosis is known to be associated with increased coronary events and poor prognosis in acute myocardial infarction (AMI). The aim of this study was to determine the significance in clinical and angiographic outcomes, success rate of the percutaneous coronary intervention (PCI) and major adverse cardiac events and event-free survival rate after PCI according to the value of peripheral monocyte on admission. METHODS: A total of 127 patients with AMI who underwent PCI between June 2000 and June 2001 at Chonnam National University Hospital were divided into two groups: Group I (n=63, 61.7+/-10.9 years, male 71.4%) with normal monocyte count (<900/mm3, mean value=536+/-202/mm3) on admission and Group II (n=64, 61.7+/-13.4 years, male 78.1%) with elevated monocyte count ( 900/mm3, mean value=1,140+/-260/mm3) on admission. RESULTS: Baseline ejection fraction was lower in Group II than in Group I (Group I; 53.3+/-13.0% vs Group II; 45.0+/-11.7%, p=0.014). The value of C-reactive protein, troponin-T and troponin-I was higher in Group II than in Group I (Group I; 2.8+/-1.9 mg/dL, 1.98+/-1.53 ng/mL, 18.3+/-17.7 ng/mL vs Group II; 5.3+/-5.0 mg/dL, 3.34+/-2.54 ng/mL, 43.1+/-24.0 ng/mL, p=0.034, 0.020, 0.006, respectively). The incidence of target lesion revascularization was higher in Group II than in Group I during hospitalization and during 6-month clinical follow-up after PCI (1.6% vs 12.5%, 19.0% vs 31.3%, p=0.012, 0.015, respectively). The event-free survival rates were lower in Group II than in Group I during hospitalization and during 6-month follow-up after PCI (96.8% vs 84.4%, 71.4% vs 53.1%, p=0.006, 0.008, respectively). CONCLUSION: Peripheral monocytosis is associated with LV dysfunction and higher incidence of target lesion revascularization and worse mid-term event-free survival during hospitalization and at 6 months after PCI in patients with AMI.
