Correlation between early renal function injury in chronic kidney disease and metabolic syndrome in elderly healthy people
10.3760/cma.j.issn.0254-9026.2022.06.011
- VernacularTitle:老年体检者慢性肾脏病早期肾功能损伤与代谢综合征的相关性分析
- Author:
Xiaoqin YAO
1
;
Yuping LIU
;
Lin WANG
;
Ping SHUAI
;
Hua YANG
;
Li JIANG
;
Xiaojiao ZUO
;
Zhi TANG
Author Information
1. 电子科技大学附属医院 四川省人民医院健康管理中心，成都 610072
- Keywords:
Kidney diseases;
Metabolic syndrome;
Renal insufficiency
- From:
Chinese Journal of Geriatrics
2022;41(6):669-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between metabolic syndrome(MS)and early renal function injury in chronic kidney disease(CKD)in the healthy elderly subjects having passed through a healthy physical examination.Methods:These healthy elderly subjects aged ≥ 60 years in the Sichuan Provincial People's Hospital health management center from September 2017 to August 2018 were randomly selected to collect lifestyle information such as disease history and living habits, as well as health information such as height, weight, waist circumference, blood pressure, fasting blood lipid, blood glucose, creatinine, morning urine routine, urinary protein and urinary occult blood.The detection situation of MS and early renal function injury of chronic kidney disease, and the correlation of MS and its abnormal components with early renal function injury of CKD were analyzed.Results:A total of 2 975 subjects, aged from 60 to 92 years old, with mean age of(67.10±5.98)years old, were enrolled.The detection rate of MS and early renal function impairment in CKD was 32.34%(962/2 975)and 28.84%(858/2 975)respectively.The detection rate of early CKD renal function injury in MS patients was 37.63%(362/962), which was higher than that in non-MS patients(24.64%)(496/2 013)( χ2=53.52, P<0.001). The prevalences of CKD and albumin/creatinine ratio(ACR)in MS patients were significantly higher than those in non-MS patients[31.91%(307/962)versus 17.49%(352/2 013)]with the difference being statistically significant( χ2=78.56, P <0.001). Central obesity, elevated blood pressure and elevated blood glucose increased the risk of CKD( OR=1.44, 1.82 and 1.74 respectively, all P< 0.05). Along with the increase of number of metabolic abnormal components, the risk of CKD increased. Conclusions:MS is a risk factor for early renal function impairment in CKD.Early control and treatment of MS are of great significance in reducing the incidence rate of CKD and delaying CKD progression.
