Relationship between cerebral small vessel disease and thyroid hormones in the elderly
10.3760/cma.j.issn.0254-9026.2022.06.009
- VernacularTitle:老年人脑小血管病与甲状腺功能相关性研究
- Author:
Wei DU
1
;
Fang LIU
;
Lei QIU
;
Juan CHEN
;
Xinxin MA
;
Wei LI
;
Lei XU
;
Yuhui CHEN
;
Yinhong LIU
Author Information
1. 北京医院保健医疗部神经内科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Keywords:
Cerebral small vessel disease;
Thyroid hormones;
White matter hyperintensity;
Cerebral microbleeds
- From:
Chinese Journal of Geriatrics
2022;41(6):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between cerebral small vessel disease and thyroid hormones in the elderly.Methods:A total of 314 subjects aged ≥60 years with records of head magnetic resonance image(MRI), serum thyroid function tests and physical examinations collected in the Department of Health Care Neurology of Beijing Hospital from May 2019 to November 2020 were consecutively included for this cross-sectional study.Participants were assigned into the cerebral small vessel disease group if their head MRI presentations met the following standards: the Fazekas score ≥3 points; the Fazekas score ≥2 points, with 1 cavity; new subcortical infarcts; or cerebral microhemorrhage.Differences in thyroid function were compared between the cerebrovascular disease group(n=129)and the group without cerebrovascular disease(control group, n=185).Results:A total of 314 subjects were enrolled, of whom 129 met the head MRI standards for cerebrovascular disease, and 185 who did not meet the standards entered the control group.Comparison of thyroid function found a statistically significant difference in FT3( t=3.270, P=0.001)between the two groups.As for the association of a specific type of cerebral small vessel disease with thyroid function, there was a statistically significant difference in the FT3 level between the lacunar infarction group and the non-lacunar infarction group( t=3.106, P=0.002)and between the cerebral microhemorrhage group and the non-cerebral microhemorrhage group( t=2.125, P=0.034). Groups with different Fazekas scores in white matter hyperintensity showed statistically significant differences in rT3( F=3.092, P=0.027), FT3( F=5.427, P=0.001)and FT4( F=2.646, P=0.049). After correction for hyperlipidemia, rT3 and FT4, it was found that age( OR=1.044, 95% CI: 1.022-1.067, P=0.000), hypertension( OR=0.533, 95% CI: 0.294-0.963, P=0.037)and FT3( OR=0.276, 95% CI: 0.159-0.478, P=0.000)were related to cerebral small vessel disease. Conclusions:FT3 levels at the lower end of the normal range are associated with cerebral small vessel disease in the elderly.
