Research progress on antiviral therapy for influenza and drug resistance in immunosuppressed patients
10.3760/cma.j.issn.1674-2397.2022.02.010
- VernacularTitle:免疫抑制患者流感病毒感染的抗病毒治疗策略及耐药研究进展
- Author:
Yafen LIU
1
;
Yan GAO
Author Information
1. 北京大学人民医院感染病科 肝病研究所 100044
- Keywords:
Influenza, human;
Immunosuppression;
Antiviral therapy;
Drug resistance
- From:
Chinese Journal of Clinical Infectious Diseases
2022;15(2):145-151
- CountryChina
- Language:Chinese
-
Abstract:
Influenza is one of the respiratory infectious diseases threatening human health, which has been widely concerned by researchers for its high morbidity and mortality. The immune function is compromised in patients receiving cancer chemotherapy, patients receiving hemopoietic stem cell transplantation or solid organ transplantation, patients on maintenance hemodialysis, and patients receiving systemic corticosteroids. Compared with immunocompetent patients, immunosuppressed patients have a longer duration of viral shedding and more antiviral resistance during influenza infections. This article reviews the antiviral therapy and related drug resistance in immunosuppressed patients with influenza, and also discusses the management of resistance to neuraminidase inhibitors and post-exposure prophylaxis in this population.
