Diagnostic value of 18F-FDG PET/CT for Richter syndrome of chronic lymphocytic leukemia
10.3760/cma.j.cn321828-20210226-00045
- VernacularTitle:18F-FDG PET/CT对慢性淋巴细胞白血病Richter综合征的诊断价值
- Author:
Chong JIANG
1
;
Yue TENG
;
Ruihe LAI
;
Chongyang DING
Author Information
1. 南京大学医学院附属鼓楼医院核医学科，南京 210008
- Keywords:
Leukemia, lymphocytic, chronic, B-cell;
Syndrome;
Positron-emission tomography;
Tomography, X-ray computed;
Fluorodeoxyglucose F18
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2022;42(7):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of 18F-FDG PET/CT in detecting Richter syndrome (RS) in chronic lymphocytic leukemia (CLL) patients. Methods:From August 2010 to November 2019, 101 histologically confirmed CLL patients (62 males, 39 females; age (58.0±12.7) years) who underwent PET/CT in Nanjing Drum Tower Hospital and the First Affiliated Hospital of Nanjing Medical University were retrospectively included. ROI was drawn and PET/CT images were semi-quantitatively examined by estimating SUV max. Mann-Whitney U test was used to compare the SUV max of RS and non-RS patients. ROC curve analysis was utilized to analyze the optimal cut-off value of SUV max in detecting RS. Results:RS was histologically confirmed in 27 CLL patients. The SUV max of RS patients was 13.7(11.0, 20.1), which was significantly higher than that of non-RS patients (4.1(3.1, 5.8); z=-6.48, P<0.001). ROC curve analysis identified the optimal cut-off value of SUV max was 10.0 and the AUC was 0.923, with accuracy of 94.1%(95/101), sensitivity of 85.2%(23/27), specificity of 97.3%(72/74), positive predictive value of 92.0%(23/25) and negative predictive value of 94.7%(72/76). Conclusion:As the semi-quantitative index measured by 18F-FDG PET/CT, SUV max can help to diagnose RS and provide important information for clinical use.
