Research progress on the mechanism of type H vessels in improving bone loss
10.3760/cma.j.cn121113-20220719-00402
- VernacularTitle:H型血管在改善骨丢失中的作用机制研究进展
- Author:
Meiling CHU
1
;
Hongfeng CHEN
;
Yulian YIN
;
Tian MENG
Author Information
1. 上海中医药大学附属龙华医院中医乳腺科，上海 200032
- From:
Chinese Journal of Orthopaedics
2022;42(22):1523-1530
- CountryChina
- Language:Chinese
-
Abstract:
In skeletal system, the coupling effect between angiogenesis and osteogenesis can promote bone growth and maintain bone mass balance. Type H vessel is a special capillary subtype in bone with high expression of Endomucin (Emcn) and CD31. The essence of type H vessel is vascular endothelial cells, mainly distributed in the metaphysis, surrounded by bone progenitor cells, which mediates the coupling mechanism of angiogenesis and osteogenesis, involving a variety of cytokines and signaling pathways. Factors including platelet-derived growth factor type BB, slit guidance ligand 3, hypoxia-inducible factor 1-alpha, Notch, and vascular endothelial growth factor are involved in the coupling of angiogenesis and osteogenesis. Type H vessels transmit signals through a variety of cytokines to enhance the connection between angiogenesis and bone formation, thus regulating bone growth and bone homeostasis. In addition, this article discusses the research prospects of improving bone loss by using it as a target, so as to provide reference for clinical bone injury repair and anti-osteoporosis treatment.
