A Clinical Experience with Althesin ( CT 1341 ) as an Induction Agent .
10.4097/kjae.1978.11.4.289
- Author:
Chang Kyum KIM
1
;
Woon Hyok CHUNG
Author Information
1. Department of Anesthesiology, Catholic Medical College, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Alfaxalone Alfadolone Mixture*;
Apnea;
Blood Pressure;
Classification;
Extremities;
Heart Rate;
Humans;
Injections, Intravenous;
Muscle, Smooth;
Respiratory Rate
- From:Korean Journal of Anesthesiology
1978;11(4):289-293
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Althesin(CT 1341), a new steroid anesthetic, was tried clinically as an induction agent. All 24 patients were in the physical status class 1 by A.S.A. classification. Dosage of althesin given intravenously was 50ul/kg B.W. and the injection speed for the given dose was 15 seconds. The following results were obtained. 1) Induction time was 42+/-19. 7 seconds. 2) No significant changes in pulse rate were found after intravenous injection of althesin. 3) Systolic blood pressure was decreased 8mmHg (p<0.01) after one minute of injection and 11 mmHg (p<0.01) after three minutes and raised to preanesthetic level after five minutes. No significant change was found in diastolic blood pressure. 4) Respiratory rate was increased 3/min. (p<0.05) after three minutes. 5) Minute volume was decreased 170Gml (p<0.01) after one minute and 700ml (p<0.05> after three minutes. 6) As complications, involuntary muscle movement of extremities was observed in two cases and transient apnea in one case.
