Research status and prospect on severe acute pancreatitis by mesenchymal stem cells treatment

VernacularTitle:间充质干细胞治疗重症急性胰腺炎的现状及展望
Author: Yue ZHANG ¹ ; Yu CHENG ; Weizheng REN ; Yiming MU
Author Information

1. 解放军总医院第一医学中心内分泌科，北京　100853
Keywords: Pancreatitis; Macrophages; Exosomes; Mesenchymal stem cells
From: Chinese Journal of Hepatobiliary Surgery 2022;28(9):717-720
CountryChina
Language:Chinese
Abstract: Severe acute pancreatitis progresses rapidly, with many complications and high mortality. Currently, the clinical treatment of severe acute pancreatitis is limited, so it is of great significance to control and treat the organ failure and long-term complications caused by severe acute pancreatitis. Mesenchymal stem cells play a beneficial role on severe acute pancreatitis therapy by promoting tissue regeneration, antioxidation, regulating autophagy and secreting anti-inflammatory factors. This paper summarized the current research status of mesenchymal stem cells on severe acute pancreatitis therapy and also showed the application of exosomes and the regulation of macrophage polarization, to provide new ideas and new targets for the treatment of severe acute pancreatitis.