The value of the albumin indocyanine green score in predicting posthepatectomy liver failure in patients with hepatocellular carcinoma
10.3760/cma.j.cn113884-20220415-00168
- VernacularTitle:白蛋白-吲哚菁绿评分预测肝细胞癌患者肝切除术后肝功能衰竭的价值
- Author:
Minqiang CHEN
1
;
Mengqiu YIN
;
Bo WU
;
Cang LI
;
Xuemin LI
;
Xiaokang WU
;
Weijian HU
;
Haihua ZHOU
;
Junfeng CHENG
;
Shian YU
Author Information
1. 浙江大学附属金华医院肝胆胰外科，金华 321000
- Keywords:
Carcinoma, hepatocellular;
Hepatectomy;
Liver failure;
Indocyanine green;
Albumin-bilirubin
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(9):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investiagte the ability of albumin-indocyanine green (ALICE) score, albumin-bilirubin (ALBI) score and Child-Pugh score in predicting postoperative liver failure (PHLF) in patients with hepatocellular carcinoma, and to determine the clinical value of ALICE score.Methods:The clinical data of 397 patients with hepatocellular carcinoma who underwent hepatectomy in the Department of Hepatobiliary and Pancreatic Surgery, Jinhua Hospital Affiliated to Zhejiang University from June 2015 to June 2021 were retrospectively analyzed, including 350 males and 47 females, aged (58.9±11.2) years. Univariate and multivariate logistic regression were used to analyze the risk factors of PHLF. The predictive ability of ALICE score for PHLF was evaluated by receiver operating characteristic (ROC) curve, and compared with ALBI score and Child-Pugh score.Results:There were 74 patients with PHLF and 323 patients without PHLF. Multivariate logistic regression analysis showed that Child-Pugh score ( OR=1.630, 95% CI: 1.251-2.486, P=0.034), ALBI score ( OR=1.863, 95% CI: 1.028-3.119, P=0.049) and ALICE score ( OR=1.759, 95% CI: 1.216-3.078, P=0.038) were independent risk factors for PHLF in patients with hepatocellular carcinoma, and the risk of PHLF increased with the increase of grade. The area under the ROC curve of ALICE score predicting PHLF in patients with hepatocellular carcinoma was 0.613 (95% CI: 0.564-0.662), the area under the ALBI score was 0.612 (95% CI: 0.563-0.661), and the area under the Child-Pugh score was 0.555 (95% CI: 0.505-0.605). The ALICE score was better than the Child-Pugh score, and the difference was statistically significant ( z=2.04, P=0.041). In small liver resection patients, ALICE score was better than Child-Pugh score ( z=2.61, P=0.009). There was no significant difference betwenn ALICE score and ALBI score ( z=0.06, P=0.954). Conclusion:ALICE score can predict the occurrence of PHLF in patients with hepatocellular carcinoma, especially in patients with small liver resection, its value is similar to ALBI score, but better than Child-Pugh score.
