Clinical, imaging and pathological features of duodenal gangliocytic paraganglioma
10.3760/cma.j.cn113884-20220104-00008
- VernacularTitle:十二指肠节细胞性副神经节瘤的临床、影像及病理特征分析
- Author:
Jizhen FENG
1
;
Zhigang YAO
;
Beibei LYU
;
Chang LU
;
Jiamei LI
Author Information
1. 山东第一医科大学附属省立医院医学影像科，济南 250021
- Keywords:
Duodenum;
Diagnosis, differential;
Gangliocytic paraganglioma
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(7):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical, imaging and pathological features of duodenal gangliocytic paraganglioma (DGP).Methods:The clinical, imaging and pathological data of patients with DGP treated at the Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2012 to October 2021 were retrospectively analyzed.Results:Of 8 patients with DGP, there were 7 males and 1 female, with a median age of 52 years (range 37 to 57 years). Five patients were asymptomatic and they were diagnosed on physical examination followed by investigations. Three patients presented with black stools. CT examination showed localized nodular thickening of the duodenum, with enhanced scanning showing obvious progressive contrast enhancement. Endoscopic ultrasonography showed a hypoechoic submucosal lesion in duodenal wall. Histologically, the neoplasm composed of three different cell types which included Schwann cells, epithelioid cells, and ganglioid cells. The Schwann cells expressed NF, NSE and S-100 proteins; the epithelioid cells expressed CK, NSE, Syn and CgA proteins; while the ganglioid cells expressed NSE, Syn, CgA and NF proteins. Endoscopic submucosal dissection was performed in 2 patients and surgical resection was performed in 6 patients.Conclusion:DGP is a rare benign neurogenic tumor which is most commonly found in the duodenum. It has a good prognosis. Imaging and endoscopic examinations demonstrated a submucosal mass. The main treatment are endoscopic resection and local surgical resection.
