A propensity score matching study on safety and efficacy of laparoscopic cholecystectomy for T2a and lower stages of gallbladder carcinoma
10.3760/cma.j.cn113884-20211204-00396
- VernacularTitle:基于倾向性评分匹配腹腔镜胆囊切除术治疗Tis~T2a期胆囊癌的安全性及疗效分析
- Author:
Ben LIU
1
;
Qingyang YAO
;
Yuting XIAO
;
Jinshu WU
;
Bo JIANG
;
Shun CHEN
;
Wei CHENG
;
Xianhai MAO
;
Xinmin YIN
;
Pin LYU
Author Information
1. 湖南师范大学附属第一医院（湖南省人民医院）肝胆外科，长沙 410005
- Keywords:
Gallbladder neoplasms;
Cholecystectomy, laparoscopic;
Surgical procedures, operative;
Propensity score matching
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(7):520-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the safety and efficacy of laparoscopic cholecystectomy (LC) in treatment of T2a and lower stages of gallbladder carcinoma.Methods:A retrospective study was performed on patients who were diagnosed with gallbladder cancer and underwent surgical treatment from January 2016 to January 2021 at Hunan Provincial People's Hospital. These patients were divided into the simple treatment group and the radical treatment group based on the surgical methods used. The simple treatment group consisted of 64 patients who underwent LC for accidental gallbladder cancers. The radical treatment group consisted of 30 patients who underwent laparoscopic radical cholecystectomy (LRC). The baseline characteristic of the two groups of patients were matched in a 1∶1 ratio using propensity score matching. After matching, there were 26 patients in each of the 2 groups. There were 7 males and 19 females in the simple group, with mean ± s. d. age of (60.6±9.6) years. There were 8 males and 18 females, with mean ± s. d. age (60.9±9.1) years in the radical treatment group. Blood loss, operation time, postoperative hospital stay, biliary leakage, acute pulmonary embolism, and incisional infection were compared between the two groups.Results:In the simple group, the operative time was (78.7±62.9) min, intraoperative blood loss was (10.7±11.6) ml and postoperative hospital stay was (4.4±2.6) d. These results were significantly better than those in the radical group with operative time (298.7±101.3) min, intraoperative blood loss (161.9±96.7) ml and postoperative hospital stay (9.9±4.0) d (all P<0.05). There were no significant difference in the postoperative complications and disease free survival rates between the two groups (both P>0.05). Conclusion:LC was safe and effective for treatment of T2a and lower stages of gallbladder cancer, and it could achieve a similar disease-free survival rate as LRC.
