Advances in research based on primary human hepatocytes in vitro

VernacularTitle:人原代肝细胞体外应用的研究进展
Author: Junning CAO ¹ ; Shichun LU
Author Information

1. 青岛大学附属医院器官移植中心，青岛　266035
Keywords: Hepatocytes; Pharmacokinetics; Drug evaluation, preclinical; Cell transplantation
From: Chinese Journal of Hepatobiliary Surgery 2022;28(6):473-477
CountryChina
Language:Chinese
Abstract: Due to the special functions of liver, the topic of liver physiological function and pathophysiological changes has always been the main issue in life science area. Human liver is composed of multiple types of cells, among which the hepatocyte is the most essential one. Primary human hepatocytes are considered as the gold standard model in vitro for the liver study and the ideal cell for hepatocyte transplantation and bioartificial liver. Nowadays, primary human hepatocytes play a vital role in the field of basic science research and applied research. Therefore, we presented recent advances in research based on primary human hepatocytes in vitro.