Research progress of circular RNA in liver disease

VernacularTitle:环状RNA在肝脏疾病中的研究进展
Author: Anzhi CHANG ¹ ; Huilai MIAO
Author Information

1. 广东医科大学附属第二医院肝胆外科　肝损伤诊断与修复重点实验室，湛江　524000
Keywords: RNA; Liver diseases; Gene expression; Research progress
From: Chinese Journal of Hepatobiliary Surgery 2022;28(6):469-473
CountryChina
Language:Chinese
Abstract: Circular RNA (circRNA) is a type of functional RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back splicing and plays an essential role in epigenetic gene expression at transcription and post-transcription levels. In recent years, more and more studies have found that circRNA are involved in occurrence and development of liver diseases, and have the potential to become biomarkers for the diagnosis and treatment of liver diseases. This article summarized the classification, formation, biological functions and roles of circRNA in different liver diseases.