Risk factors of development of combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma
10.3760/cma.j.cn113884-20220302-00081
- VernacularTitle:混合型肝癌及肝内胆管癌的危险因素分析
- Author:
Zhenwei YANG
1
;
Zeyuan QIANG
;
Kunfu DAI
;
Qingshan LI
;
Zhiyuan REN
;
Haibo YU
Author Information
1. 河南大学人民医院（河南省人民医院）肝胆胰腺外科，郑州 450003
- Keywords:
Liver neoplasms;
Cholangiocarcinoma;
Risk factors;
Hepatitis B virus
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(6):435-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the risk factors for development of combined hepatocellular-cholangiocarcinoma (CHC) and intrahepatic cholangiocarcinoma (ICC).Methods:The clinical data of patients with ICC or CHC confirmed by pathology at Henan Provincial People's Hospital from January 2012 to December 2018 were retrospectively analyzed. Of 225 patients with ICC or CHC, there were 90 males and 135 females, aged (58.7±10.4) years old. Based on the pathological type, there were 172 patients in the ICC group and 53 patients in the CHC group. The healthy control group was selected from 450 individuals who underwent routine health examination in the same hospital, and there were 189 males and 261 females, aged (56.7±9.3) years old. Univariate and multivariate logistic regression were used to analyze the risk factors of ICC and CHC.Results:The risk factors of ICC included hepatitis B surface antigen (HBsAg) (+ )/hepatitis B core antibody (anti-HBc) (+ ) ( OR=9.373, 95% CI: 4.784-18.363, P<0.001), hepatitis C virus antibody (HCV-Ab) (+ ) ( OR=7.151, 95% CI: 1.195-42.776, P=0.031), diabetes mellitus ( OR=3.118, 95% CI: 1.733-5.612, P<0.001) and hepatolithiasis ( OR=18.650, 95% CI: 5.210-66.767, P<0.001). The risk factors of CHC included HBsAg (+ )/anti-HBc(+ )( OR=54.891, 95% CI: 17.434-172.822, P<0.001) and HCV-Ab (+ ) ( OR=37.785, 95% CI: 5.720-249.611, P<0.001). Conclusion:HBV infection, HCV infection, hepatolithiasis, diabetes mellitus and cirrhosis were risk factors for ICC. HBV and HCV infection were risk factors of CHC.
