Risk factors for acute kidney injury after adult orthotopic liver transplantation
10.3760/cma.j.cn113884-20220211-00056
- VernacularTitle:成人原位肝移植受者术后急性肾损伤的危险因素分析
- Author:
Haocheng YU
1
;
Peihao WEN
;
Jiakai ZHANG
;
Yuting HE
;
Shuijun ZHANG
;
Wenzhi GUO
Author Information
1. 郑州大学第一附属医院肝胆胰外科 河南省器官移植中心 河南省器官移植医学工程技术中心，郑州 450052
- Keywords:
Liver transplantation;
Acute kidney injury;
Risk factors
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(6):408-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors for acute kidney injury (AKI) after adult orthotopic liver transplantation.Methods:The clinical data of 232 recipients who underwent orthotopic liver transplantation at the First Affiliated Hospital of Zhengzhou University from January 2019 to April 2021 were retrospectively analyzed. There were 195 males and 37 females, aged (49.1±9.4) years old. The patients were divided into two groups according to whether AKI had occurred within 7 days of surgery into the AKI group ( n=112) and the non-AKI group ( n=120). Clinical data including basic information, preoperative hematological indexes, operation time and postoperative hospital stay were compared between the two groups. Factors associated with AKI after orthotopic liver transplantation were studied using univariate analysis and those factors with significant differences were included in multifactorial logistic regression analysis. Results:Among 232 patients who underwent orthotopic liver transplantation, 112 patients developed AKI after surgery, with an incidence of 48.3% (112/232). There were 64 patients with AKI stage 1 (57.1%, 64/112), 30 patients with AKI stage 2 (26.8%, 30/112), and 18 patients with AKI stage 3 (16.1%, 18/112). Logistic regression analysis showed that hypertension ( OR=5.874, 95% CI: 1.931-17.863, P=0.002) and high scores on the model for end-stage liver disease (MELD) ( OR=1.041, 95% CI: 1.010-1.074, P=0.010) were independent risk factors for AKI after orthotopic liver transplantation. Conclusion:Hypertension and MELD score were independent risk factors for postoperative AKI in orthotopic liver transplant recipients.
