Advances in prevention and treatment of radiation-induced lymphopenia

VernacularTitle:放射治疗诱发淋巴细胞减少的预防和治疗进展
Author: Xuran ZHAO ¹ ; Guangyi SUN ; Shulian WANG
Author Information

1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京　100021
Keywords: Radiotherapy; Lymphopenia; Prevention; Treatment
From: Chinese Journal of Radiation Oncology 2022;31(12):1190-1194
CountryChina
Language:Chinese
Abstract: Currently, radiotherapy has been found to induce lymphopenia in multiple solid tumors, which has been proven to be associated with poor prognosis. Radiation-induced lymphopenia (RIL) is associated with age, baseline lymphocyte count, tumor size and location and radiotherapy regimens (radiation fractionation, field size and technique), etc. In addition, several drugs and cytokines may help restore lymphocytes. Exploration of effective strategies to prevent or treat RIL may be an important future direction to improve prognosis of cancer patients.