Radiosensitization mechanism of metformin and analysis of clinical application prospect
10.3760/cma.j.cn113030-20210408-00142
- VernacularTitle:二甲双胍的放疗增敏机制及临床应用前景分析
- Author:
Xin XIONG
1
;
Xingwen FAN
Author Information
1. 复旦大学上海医学院，上海 200032
- Keywords:
Metformin;
Radiotherapy;
Radiosensitization
- From:
Chinese Journal of Radiation Oncology
2022;31(10):966-970
- CountryChina
- Language:Chinese
-
Abstract:
Metformin is the basic drug for type 2 diabetes mellitus. More and more studies have shown that metformin has anti-tumor effect, and its radiosensitization effect has been gradually found. Metformin can increase the radiosensitivity of tumor cells by improving hypoxia, increasing reactive oxygen species, inhibiting DNA damage repair, inducing cell cycle arrest and regulating immune microenvironment. However, several recently published randomized controlled trials have not confirmed that metformin can increase the efficacy of chemoradiotherapy. In this review, the mechanism and clinical results of metformin radiosensitization were summarized. The dose of metformin will be an important factor for basic and clinical research in the future.
