Research progress on the mechanism of cell pyroptosis signaling pathways in radiation injury

VernacularTitle:细胞焦亡信号通路在放射损伤中的研究进展
Author: Jun ZHANG ¹ ; Yongsheng ZHANG ; Zhifei CAO
Author Information

1. 苏州大学附属第二医院病理科，苏州　215004
Keywords: Pyroptosis; Radiotherapy; Radiation injury; Ionizing radiation; Gasdermin family
From: Chinese Journal of Radiological Medicine and Protection 2022;42(10):817-822
CountryChina
Language:Chinese
Abstract: Pyroptosis is an inflammatory programmed cell death. Unlike apoptosis, pyroptosis is always accompanied by inflammation. It has been found that cell pyroptosis is closely related to the occurrence and development of many diseases. Pyroptosis also plays an important role in radiation injury caused by radiotherapy. Ionizing radiation breaks DNA in cells and induces oxygen free radicals, which are good inducers of pyroptosis. Therefore, this paper reviewed the research progress on the mechanism of cell pyroptosis in radiation injury from the perspective of relative signaling pathways, in order to provide new ideas for weakening or blocking radiation injury.