Clinical value of Ki-67 and human epidermal growth factor receptor 2 in stage Ⅲ-Ⅳ A salivary duct carcinoma
10.3760/cma.j.cn112271-20220715-00293
- VernacularTitle:Ki-67和人表皮生长因子受体-2在Ⅲ~Ⅳ A期唾液腺导管癌中的临床价值
- Author:
Xiaoxu LU
1
;
Junjie WANG
;
Xueming SUN
;
Rong HUANG
;
Hui WU
Author Information
1. 郑州大学附属肿瘤医院/河南省肿瘤医院放疗科，郑州 450008
- Keywords:
Ki-67;
Human epidermal growth factor receptor 2;
Salivary duct carcinoma;
Prognosis
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(10):753-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of Ki-67 and human epidermal growth factor receptor 2 (HER-2) in salivary duct carcinoma in stage Ⅲ-Ⅳ A. Methods:The data of 52 cases of locally advanced salivary duct carcinoma(SDC) diagnosed from January 2012 to December 2020 were retrospectively analyzed. All patients underwent radical surgery and postoperative radiotherapy. Among them, 15.4% of patients had local recurrence, 28.8% had distant metastasis, 17.3% had regional recurrence with distant metastasis. The relationship between clinical features, pathological features such as Ki-67 and HER-2 and prognosis such as local recurrence and distant metastasis was analyzed.Results:The average follow-up time was 37.6 months. The 1- and 2-year local recurrence free survival, distant metastasis free survival, progression free survival were 86.5%, 73.1%, 65.4% and 67.3%, 55.8%, 46.2% respectively. The 3-year progression free survival rate was 33.3%. Comparison between groups showed that age ≥ 65 years old, T stage, TNM stage, vascular tumor thrombus, radiotherapy dose <60 Gy, Ki-67 positive index and HER-2 positive were related to the prognosis of different stages. In multivariate analysis, only age, Ki-67 positive index ≥ 60% and HER-2 protein (3+ ) were independent poor prognostic factors for locally advanced SDC ( t =5.16, 9.84, 8.23, P<0.05). Conclusions:In stage Ⅲ-Ⅳ A SDC, only radical surgery and postoperative radiotherapy have a high rate of distant metastasis. Ki-67 positive index and HER-2 positive are independent adverse prognostic factors.
