Roles of STAT3 in radiation response, tumor progression and tissue repair
10.3760/cma.j.cn112271-20220608-00246
- VernacularTitle:STAT3在电离辐射响应、肿瘤发展以及组织修复中的作用
- Author:
Shuai DONG
1
;
Haisheng LIANG
;
Lei CHANG
;
Peng ZHANG
Author Information
1. 苏州大学医学部放射医学与防护学院 放射医学与辐射防护国家重点实验室 江苏省高校放射医学协同创新中心，苏州 215123
- Keywords:
STAT3;
Ionizing radiation;
Tumor progression;
Tumor microenvironment;
Tissue reparation
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(9):722-726
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription (STAT) is a family of cytoplasmic transcription factors including seven proteins of STAT-1, -2, -3, -4, -5A, -5B and -6. The genes encoding the STAT family are located on are located on chromosome 2 (STAT1 and STAT4), chromosome 12 (STAT2 and STAT6) and chromosome 17 (STAT3, STAT5A and STAT5B). Among these seven proteins, STAT3 and STAT5 have the strongest correlation with tumor progression, and ionizing radiation can affect STAT3 level. Continuous activation of STAT3 can regulate a variety of functions, including cell proliferation, cell cycle progression, apoptosis, angiogenesis and immune escape. STAT3 is highly complex in its biological function and activator action. Therefore, it is of great significance to further study the biological function and signaling pathway of STAT3.
