Study on the correlation of integr in associated protein and disease activity and bone destruction in patients with rheumatoid arthritis
10.3760/cma.j.cn141217-20211231-00531
- VernacularTitle:整合素相关蛋白与类风湿关节炎疾病活动及骨破坏相关性研究
- Author:
Xue WU
1
;
Fang SHI
;
Xiuqing YAN
;
Fengmei GE
;
Zhao LI
;
Qiushuang ZHANG
;
Qu CHEN
;
Qi CHEN
;
Xuebin WANG
Author Information
1. 滨州医学院附属医院风湿免疫科，滨州 256603
- Keywords:
Arthritis, rheumatoid;
Integrin-associated proteins;
Thrombospondin-1;
Disease activity;
Bone destruction
- From:
Chinese Journal of Rheumatology
2022;26(9):603-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the serum levels of integrin-associated proteins (CD47) in patients with rheumatoid arthritis (RA), and to explore its association with disease activity and bone destruction in RA.Methods:Serum and clinical data were collected from 65 RA patients and 25 healthy subjects. RA patients were grouped into low, moderate, and high bone erosion groups according to 7-joint ultrasonography score (US7). The levels of serum CD47, thrombospondin-1 (TSP-1) and receptor activator of nuclear factor-κB ligand (RANKL) were measured by enzyme-linked immunosorbnent assay (ELISA) in patients with RA and healthy subjects. The statistical analysis was carried out with independent t-test, analysis of variance, nonparametric rank sum test, pearson or Spearman correlation and logistic regression. Results:① The Serum levels of CD47, TSP-1, and RANKL were higher in the RA group than in the healthy controls ( P<0.01). ② In RA patients, serum CD47 level was positively correlated with disease course ( r=0.301, P<0.05), C-reactionprotein (CRP)( r=0.316, P<0.05), number of tender joints (TJC) ( r=0.254, P<0.05), number of swollen joints (SJC) ( r=0.316, P<0.05), disease activity score in 28 joints (DAS28) ( r=0.255, P<0.05), RANKL ( r=0.252, P<0.05) and TSP-1 ( r=0.260, P<0.05). Serum TSP-1 level was positively correlated with CRP ( r=0.299, P<0.05), TJC ( r=0.335, P<0.01), DAS28 ( r=0.315, P<0.05), RANKL ( r=0.305, P<0.05). ③ The disease course [ OR(95% CI)=1.048(1.033, 1.017)] and TSP-1 [ OR(95% CI)=1.013(1.000, 1.026)] were independently relevant factors affecting bone destruction. Conclusion:CD47 levels is significantly higher in RA patients than in healthy controls, and is associated with disease activity and bone destruction. CD47 may be involved in the bone destruction process of RA by acting on TSP-1.
