Effects of menopause on depressive and anxiety symptoms in community women in Beijing
10.3760/cma.j.cn112141-20220208-00064
- VernacularTitle:绝经对抑郁焦虑症状的影响：北京市社区女性队列调查
- Author:
Ruiyi TANG
1
;
Min LUO
;
Yubo FAN
;
Zhuolin XIE
;
Feiling HUANG
;
Duoduo ZHANG
;
Gaifen LIU
;
Yaping WANG
;
Shouqing LIN
;
Rong CHEN
Author Information
1. 中国医学科学院北京协和医学院北京协和医院妇产科 国家妇产疾病临床医学研究中心，北京 100730
- Keywords:
Menopause;
Depressive;
Anxiety;
Cohort studies
- From:
Chinese Journal of Obstetrics and Gynecology
2022;57(6):419-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the effects of menopausal stage, age and other associated risk factors on symptoms of anxiety and depression among women in a community in Beijing.Methods:This study was a community-based prospective cohort. Participants who had transitioned through natural menopause, completed two or more depressive and anxiety symptoms evaluations, aged 35 to 64 years, and did not use hormone therapy were selected from the Peking Union Medical College Hospital aging longitudinal cohort of women in midlife to this analysis. The primary outcome variables were depressive and anxiety symptoms, assessed by hospital anxiety and depression scale (HADS). The generalized estimation equation was used in the statistical analysis.Results:Followed up from 2006 to 2014, 430 women and 2 533 HADS assessments were retained in the cohort. Depressive symptoms were more common than anxiety symptoms during all menopausal stages. The incidences of depressive and anxiety symptoms were 14.5% (19/191) and 3.1% (4/191) in the premenopausal -3 stage, respectively. The incidence increased in both menopausal transition and postmenopausal stage, with the highest incidence in the +1c stage [20.6% (155/751) and 8.8% (66/751), respectively]. However, these differences were not statistically significant (all P>0.05). Depressive symptoms were highest in the ≥60-<65 age group [20.8% (74/355)], and anxiety symptoms were highest in the ≥50-<55 age group [8.2% (62/754)]; but there were no statistical significances between different age groups and depressive and anxiety symptoms (all P>0.05). Multivariable analysis showed that high body mass index, low education status, and poor health status were independently associated with depressive symptoms (all P<0.05), and that poor health status, trouble falling asleep, and early awakening were independently associated with anxiety symptoms (all P<0.01). Conclusions:Depressive and anxiety symptoms are more common during menopausal transition and postmenopausal stage compared with reproductive stage. Depressive symptoms are more common than anxiety symptoms. To screen and assess depressive and anxiety symptoms in perimenopausal women is essential, especially for women with high risk factors.
