Application value of transrectal multimodal ultrasound in evaluating the efficacy of endocrine therapy for prostate cancer
10.3760/cma.j.cn131148-20220207-00084
- VernacularTitle:经直肠多模态超声在前列腺癌内分泌治疗效果评估中的应用价值
- Author:
Qian LIU
1
;
Hua HONG
;
Danyan LIANG
;
Guozhu WU
;
Ran SUN
;
Fang WANG
;
Yue SUN
;
Yuan FENG
Author Information
1. 内蒙古自治区人民医院超声医学科，呼和浩特 010017
- Keywords:
Ultrasonography, transrectal;
Prostate cancer;
Endocrine therapy;
Contrast-enhanced ultrasound;
Elastography
- From:
Chinese Journal of Ultrasonography
2022;31(9):802-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of transrectal multimodal ultrasound parameters in monitoring and evaluating the efficacy of endocrine therapy for prostate cancer.Methods:Thirty patients with prostate cancer confirmed by pathology and treated with endocrine therapy in Inner Mongolia Autonomous Region People′s Hospital from November 2019 to May 2021 were selected. The levels of serum prostate specific antigen (PSA), prostate volume, color Doppler parameters, elasticity index and contrast-enhanced ultrasound parameters were measured and recorded before treatment, 1 month and 3 months after treatment. The parameters before and after treatment were statistically analyzed. The correlation between the changes of each index and PSA was analyzed by Spearman correlation analysis.Results:Total prostate specific antigen, free prostate specific antigen, and prostate volume were significantly different before treatment, and 1 month and 3 months after treatment( P<0.05), and the values showed a downward trend with increase of treatment time. There was no significant difference in resistance index before and 1 month after treatment( P>0.05), but decreased significantly 3 months after treatment( P<0.05). The values of elasticity index, peak intensity, area under curve and gradient at 1 month and 3 months after treatment were lower than those before treatment, while the arrival time and rising time at 1 month and 3 months after treatment were significantly higher than those before treatment( P<0.05). Spearman correlation analysis showed that there was no correlation between the changes of quantitative parameters and PSA value before and after treatment( P>0.05). Conclusions:Prostate volume, color Doppler parameters, elasticity index, and contrast-enhanced ultrasound parameters change in the early stage of endocrine therapy for prostate cancer, which can be used as a useful supplement to PSA for prostate cancer, and can be used to evaluate the efficacy of clinical prostate cancer endocrine therapy.
