Research progress concerning the signaling pathway mechanisms related to mechanical stress-induced bone regeneration
10.3760/cma.j.cn115530-20220123-00045
- VernacularTitle:机械应力介导骨组织再生相关信号通路机制的研究进展
- Author:
Yifan YU
1
;
Jia XU
;
Qinglin KANG
Author Information
1. 上海交通大学医学院附属第六人民医院骨科，上海 200233
- Keywords:
Mechanical stress;
Bone regeneration;
Signal transduction;
Ilizarov technique
- From:
Chinese Journal of Orthopaedic Trauma
2022;24(10):916-920
- CountryChina
- Language:Chinese
-
Abstract:
Elucidation of the signaling pathway mechanisms related to the mechanical stress-mediated bone regeneration is of great significance for improvement of bone regeneration and clinical treatment of bone-related diseases such as bone defects and bone elongation. Mechanical stress transmits mechanical stimuli into cells through the piezo channels and integrins, causing a variety of signaling pathway responses, which in turn changes transcription factor translocation, gene expression, and osteoblast differentiation to promote bone regeneration ultimately. This article reviews the research progress concerning the mechanisms related to mechanical stress-mediated bone tissue regeneration.
