Research progress in the role of the complement system in post-traumatic immunity

VernacularTitle:补体系统在创伤后免疫中作用的研究进展
Author: Shengyu HUANG ¹ ; Guanghua GUO ; Feng ZHU
Author Information

1. 南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌　330006
Keywords: Wounds and injuries; Complement activation; Immune system
From: Chinese Journal of Trauma 2022;38(9):857-864
CountryChina
Language:Chinese
Abstract: Trauma can trigger systemic pathological states, including coagulation disorders, tissue damage and metabolic disturbances, in which immune responses are extensively involved and play an important role. As an important component of innate immunity, the complement system is known to be implicated in the bactericidal process of lysis in vivo and can also induce immune inflammation in the body, but its role in trauma is not clear. The authors summarize the interaction between complement system activation and immune system, and the clinical translation of complement system intervention after trauma from the aspects of posttraumatic innate immunity, acquired immunity as well as there internal bridging, in order to provide more ideas for clinical trauma treatment.