Management and research progress of Wilson disease in pregnancy
10.3760/cma.j.cn101721-20220507-000172
- VernacularTitle:妊娠合并肝豆状核变性的管理及研究进展
- Author:
Zikun MA
1
;
Xinyan ZHAO
Author Information
1. 首都医科大学附属北京友谊医院肝病中心 国家消化系统疾病临床医学研究中心，北京 100050
- Keywords:
Wilson's disease;
Pregnancy;
Clinical features;
Management
- From:
Clinical Medicine of China
2022;38(5):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical characteristics, management and prognosis of pregnancy in WD are special and less reported, which are the key and difficult problems concerned by clinicians. Regardless of whether they receive treatment or not, pregnant women with WD may have disease progression or even death, and their fetuses are also faced with the risk of genetic disease, malformation and death. Domestic and foreign guidelines suggest that during pregnancy, drugs such as D penicillamine and zinc should continue to be taken to remove copper, however breast-feeding is not recommended now. Although the safety of treatment drugs and breastfeeding in WD needs to be further evaluated, the benefits of appropriate copper removal treatment still outweigh the disadvantages. Most women of childbearing age with WD can successfully conceive and deliver after receiving appropriate copper removal treatment and pre pregnancy consultation.
