Research progress on the relationship between Klotho and the growth of children and newborns

VernacularTitle:Klotho蛋白与儿童及新生儿生长关系的研究进展
Author: Mengyuan CAO ¹ ; Yaying CHENG ; Ran ZHOU
Author Information

1. 河北省人民医院儿科，石家庄　050051
Keywords: Klotho; Growth hormone; Insulin-like growth factor 1; Linear growth; Small for gestational age
From: Clinical Medicine of China 2022;38(4):369-373
CountryChina
Language:Chinese
Abstract: Klotho is a gene associated with aging, the transmembrane protein encoded by this gene is highly expressed in the kidney, and is also expressed in tissues such as the brain, parathyroid and pituitary glands. The extracellular domain of Klotho can also be cleaved and shed to form soluble Klotho, which acts as a circulating hormone and can be detected in blood, cerebrospinal fluid, and urine. More and more studies have shown that Klotho protein plays an important role in the complex regulation of growth hormone (GH)-insulin-like growth factor 1(IGF1) axis. The interaction between Klotho protein and GH-IGF1 axis is bidirectional, which regulates each other, and then regulates the normal linear growth of children. In addition, Klotho protein can also affect the growth and development of fetus and newborn through different ways, and its mechanism is not very clear.