The exploration of infertility′s pathogenesis through gene editing technology
10.3760/cma.j.cn431274-20221019-01040
- VernacularTitle:利用基因编辑技术探索不孕症发病机制的研究进展
- Author:
Zeyu XIONG
1
;
Chunhui ZHANG
;
Weiping QIAN
Author Information
1. 北京大学深圳医院生殖医学中心，深圳 518035
- Keywords:
Infertility, female;
Gene editing;
Genital diseases, female;
Disease models, animal
- From:
Journal of Chinese Physician
2022;24(11):1601-1605
- CountryChina
- Language:Chinese
-
Abstract:
Recently, the incidence rate of infertility has been increasing year by year. Lesions of the female reproductive system are the most important causes of infertility, such as premature ovarian failure, polycystic ovary syndrome, pelvic inflammatory disease, endometriosis, recurrent abortion, etc. However, the specific pathogenesis of infertility needs to be further studied. Gene editing is a technical method to change the sequence of deoxyribonucleic acid (DNA) in biological cells, which is an indispensable tool for studying gene function and disease pathogenesis. In this research, we review the recent progress in studying the pathogenesis of female infertility related diseases through gene editing technology, so as to explore a new direction for the clinical diagnosis and treatment of infertility.
