Network meta-analysis of efficacy of Chinese medicine injection in treatment of heart failure after acute myocardial infarction
10.3760/cma.j.cn431274-20220112-00027
- VernacularTitle:中药注射液治疗急性心肌梗死后心力衰竭疗效的网状meta分析
- Author:
Dongying WANG
1
;
Xunan GUO
;
Yunfei BIAN
Author Information
1. 山西医科大学第二临床医学院，太原 030001
- Keywords:
Myocardial infarction;
Heart failure;
Shenmai injection;
Shenfu injection;
Xinmailong injection;
Meta-analysis
- From:
Journal of Chinese Physician
2022;24(10):1479-1487,1492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to systematically evaluate the efficacy of Chinese medicine injection (CMI) in the treatment of heart failure (HF) after acute myocardial infarction (AMI).Methods:China National Knowledge Infrastructure (CNKI), WanFang Data, VIP, The Cochrane Library, PubMed, and EMbase databases were electronically searched from inception to October 2021 to identify randomized controlled trials (RCTs) on CMI for treating HF after AMI. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Network meta-analysis was then performed by ADDIS1.16.6 software and Stata 16.0 software.Results:A total of 55 studies were included involving 4 760 patients with HF after AMI and 3 types of CMIs, including Shenmai, Shenfu, Xinmailong injections. The results of network meta-analysis showed that Xinmailong injection was superior to Shenmai injection and Shenfu injection in improving the total effective rate and reducing left ventricular end diastolic diameter (LVEDD); Shenmai injection was superior to Xinmailong injection and Shenfu injection in reducing B-type natriuretic peptide (BNP); Shenfu injection was superior to Shenmai injection and Xinmailong injection in increasing left ventricular ejection fraction (LVEF) and reducing heart rate (HR).Conclusions:The combined 3 types of CMIs for treating HF after AMI can improve the clinical efficacy when compared with conventional Western medicine treatment. Among them, Xinmailong injection is better in improving the total effective rate and reducing LVEDD, Shenmai injection is more advantageous in reducing BNP, and Shenfu injection has the best efficacy in improving LVEF and reducing HR.
