Research process on pathogenesis of gastroesophageal reflux disease
10.3760/cma.j.cn431274-20211019-01090
- VernacularTitle:胃食管反流病发病分子机制研究进展
- Author:
Tuerhong YALIKUN
1
;
Yisireyili MAIMAITI
;
Abudureyimu KELIMU
Author Information
1. 新疆维吾尔自治区人民医院微创，疝和腹壁外科，乌鲁木齐 830001
- Keywords:
Gastroesophageal reflux;
NF-kappa B;
Receptor 2, proteinase-activated;
5-hydroxytryptamine
- From:
Journal of Chinese Physician
2022;24(9):1425-1428
- CountryChina
- Language:Chinese
-
Abstract:
Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity, causing symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. Heartburn is the sensation of burning or discomfort behind the sternum. Heartburn may radiate into the neck, is typically worse after meals or when in a reclining position, and may be eased by antacids. Regurgitation is the backflow of gastric contents into the mouth or hypopharynx. Epigastric pain can also be a symptom of GERD. Extraesophageal symptoms of GERD include dental erosions, laryngitis, cough, and asthma. In recent years, great progress has been made in understanding the molecular basis of GERD, suggesting that its pathogenesis is more complex and multifactorial. In this paper, the molecular pathogenesis was taken as the starting point, including the mechanism of genes in the pathogenesis and development of GERD, the mechanism of NF-κB pathway in the pathogenesis and development of GERD, the role of proteinase-activated receptor-2 in the pathogenesis of GERD, the association between abnormal serotonin pathway and GERD, and the relationship between reactive oxygen species and GERD, to summarize the pathogenesis of gastroesophageal reflux disease.
