Research progress on the role of intestinal flora in the pathogenesis of gastroesophageal reflux disease

VernacularTitle:肠道菌群在胃食管反流病发病中的作用及相关性研究进展
Author: Kasimu AIHEMAITI ¹ ; Yisireyili MAIMAITI ; Abudureyimu KELIMU
Author Information

1. 新疆维吾尔自治区人民医院微创，疝和腹壁外科，乌鲁木齐　830001
Keywords: Gastroesophageal reflux; Intestinal flora; Metabolic diseases; Immunity
From: Journal of Chinese Physician 2022;24(8):1273-1276
CountryChina
Language:Chinese
Abstract: Gastroesophageal reflux disease (GERD) is a global digestive system disease caused by the reflux of gastric contents into the esophagus and the injury of esophageal mucosa. At present, the pathogenesis of GERD is not completely clear. Studies have found that GERD is closely related to intestinal flora disorder and small intestine bacterial overgrowth (SIBO). Changes in intestinal flora can participate in the occurrence and development of GERD by activating immune and inflammatory reactions, affecting gastroesophageal motility and other mechanisms. In addition, intestinal flora can also indirectly regulate and affect the pathogenesis of GERD by causing some metabolic diseases. This paper aims to review the relationship between GERD and intestinal flora.