Evaluation value of atherogenic index of plasma for long-term prognosis of coronary artery disease
10.3760/cma.j.cn431274-20211114-01185
- VernacularTitle:血浆致动脉硬化指数对冠心病远期预后的评估价值
- Author:
Yongliang ZHAO
1
;
Shaohui ZHANG
;
Qiang SU
;
Wen DAI
;
Lixin LIU
;
Guoliang YANG
;
Anyong CHEN
;
Xueying CHEN
Author Information
1. 济宁医学院附属医院心外科，济宁 272029
- Keywords:
Coronary artery disease;
Atherogenic index of plasma;
Triglyceride;
High-density lipoprotein cholesterol;
Major adverse cardiac events
- From:
Journal of Chinese Physician
2022;24(8):1204-1209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the predictive value of atherogenic index of plasma (AIP) on the long-term prognosis of patients with coronary artery disease (CAD).Methods:A total of 2 500 patients with coronary heart disease who underwent coronary angiography in Affiliated Hospital of Jining Medical University from May 2013 to November 2015 were retrospectively analyzed. According to the AIP value, the subjects were divided into low AIP group (AIP<0.06) and high AIP group (AIP≥0.06). The incidence of major adverse cardiovascular events (MACE) was compared between the two groups. Kaplan-meier method was used to evaluate the MACE-free survival rate, and multivariate Cox survival analysis was used to evaluate the independent predictors of MACE.Results:A total of 2 427 patients were followed up, with a follow-up rate of 97.08% and a median follow-up time of 4.29 years. There were 1 123 cases in the low AIP group and 1 304 cases in the high AIP group, among which 624 patients (25.7%) had MACE. The total incidence of MACE in the high AIP group was higher than that in the low AIP group ( HR=1.43, 95% CI: 1.22-1.68, P<0.01). Kaplan-meier curves showed that the MACE-free survival rate was significantly lower in the high AIP group ( P<0.01). After adjusting for multiple confounding factors, AIP was still associated with the prognosis of CHD patients. Increased AIP (≥0.06) was an independent predictor of MACE in CHD patients within 4 years ( HR=1.34, 95% CI: 1.14-1.58, P<0.01). Conclusions:AIP (≥0.06) was an independent predictor of MACE occurrence in patients with CAD within 4 years. AIP has a certain value in the long-term prognosis of patients with CAD.
