Changes of microstructure of white matter and clinical high risk for psychosis
10.3760/cma.j.cn371468-20220421-00193
- VernacularTitle:脑白质微结构改变与精神病临床高危
- Author:
Zhenzhu CHEN
1
;
Qijing BO
;
Lei ZHAO
;
Yuan ZHOU
;
Chuanyue WANG
Author Information
1. 首都医科大学附属北京安定医院，国家精神心理疾病临床医学研究中心，精神疾病诊断与治疗北京市重点实验室，北京脑重大疾病研究院精神分裂症研究所，北京 100088
- Keywords:
Clinical high-risk for psychosis;
Ultra-high risk;
Diffusion tensor imaging;
White matter microstructure;
White matter integrity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(12):1137-1142
- CountryChina
- Language:Chinese
-
Abstract:
The research on clinical high-risk for psychosis is a hotspot in recent years, which is helpful to the early identification and early intervention of psychosis. White matter fibers are the important structural basis of complex information transmission function among brain regions. The existing literatures show that there are abnormal white matter microstructures in individuals at clinical high-risk for psychosis, which is related to their clinical symptoms and social function. Diffusion tensor imaging is the only non-invasive technique to study the microstructure of brain white matter. This paper reviews the existing evidences of microstructural abnormalities of white matter at clinical high-risk for psychosis by diffusion tensor imaging, in order to comprehensively analyze the potential neurobiomarkers in the early stage of the disease and the pathological evolution characteristics in the development of the disease.
