Association of N-cadherin (CDH2) polymorphisms with schizophrenia susceptibility and clinical symptoms in Han Chinese population
10.3760/cma.j.cn371468-20220901-00507
- VernacularTitle:豫北汉族人群CDH2基因多态性与精神分裂症发病及临床症状的关联分析
- Author:
Changle ZHAO
1
;
Xi SU
;
Yongfeng YANG
;
Meng SONG
;
Minglong SHAO
;
Yan ZHANG
;
Luxian LYU
;
Wenqiang LI
Author Information
1. 新乡医学院第二附属医院；河南省精神病医院；河南省生物精神病学重点实验室，新乡 453002
- Keywords:
Schizophrenia;
N-cadherin;
Single nucleotide polymorphisms;
Clinical symptom;
Association analyses
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(12):1080-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective:A case-control association analysis was performed to investigate if the single nucleotide polymorphisms (SNPs) of N-cadherin(CDH2) gene is implicated in schizophrenia in a Han Chinese population.Methods:A total of 528 patients with paranoid schizophrenia and 528 healthy controls were recruited from northern Henan province to analyze 25 SNPs located in CDH2 gene.The clinical symptoms of 267 first-episode schizophrenia patients were evaluated with positive and negative syndrome scale (PANSS), and the correlation between CDH2 gene and clinical symptoms was analyzed by SNPStats software online.Results:Allele frequencies of rs9951577 and rs1231268 were significantly correlated with schizophrenia( P<0.05), genotype frequency of rs1639387 was significantly correlated with schizophrenia( P=0.044). After gender classification, SNPs rs1789470 and rs28365328 were found to be significantly correlated with schizophrenia in female patients ( P=0.044, 0.019). In addition, the study found that CDH2 was correlated with the clinical characteristics of schizophrenia( P<0.05), and the negative factor score of patients between GG type rs1231268 and the other two genotypes (AG+ AA) ((21.12±8.41) vs (18.87±7.52)) was statistically significant ( P<0.05). Conclusion:CDH2 gene may be one of the susceptibility genes to SZ, and has definite correlation with clinical negative symptoms.
