Effects of intermittent theta-burst stimulation on functional connectivity in patients with mild cognitive impairment
10.3760/cma.j.cn371468-20220605-00306
- VernacularTitle:间歇性θ短阵脉冲刺激对轻度认知功能障碍患者脑电功能连接的影响
- Author:
Yuxing KUANG
1
;
Rui XIA
;
Jing XIE
;
Ziyi WU
;
Xingjie LI
;
Jun LIU
;
Yalan DAI
;
Mengyang WANG
;
Dan WANG
;
Shangjie CHEN
Author Information
1. 南方医科大学第二临床医学院，深圳市宝安区人民医院，深圳 518101
- Keywords:
Intermittent theta-burst stimulation;
Mild cognitive impairment;
Functional connectivity;
Phase lag index;
Dorsolateral prefrontal cortex
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(11):984-989
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of single intermittent theta-burst stimulation on functional connectivity in patients with mild cognitive impairment(MCI).Methods:From July to November 2020, forty MCI patients were selected and randomly divided into iTBS true stimulation group and iTBS sham-stimulation group, with 20 patients in each group.iTBS targeted the left dorsolateral prefrontal cortex (DLPFC). Montreal cognitive assessment (MoCA), mini-mental state examination (MMSE), activity of daily living scale(ADL), Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were evaluated at baseline.The resting state electroencephalography (rsEEG) was collected for 5 minutes before and after iTBS in the two groups.The phase lag index(PLI) of EEG functional connectivity was calculated, and the functional connectivity matrix diagram was drawn.SPSS 26.0 software was used for statistical analysis.Data were statistically analyzed by χ2 test, Wilcoxon rank sum test and independent sample t-test. Results:There were no significant differences in scores of MoCA, ADL, HAMD and HAMA between the two groups(all P>0.05). In the iTBS true stimulation group, compared with that before iTBS treatment(0.140(0.133, 0.144)), the PLI of β band increased significantly after iTBS treatment(0.146(0.136, 0.167))( P<0.05). The region of increased PLI was mainly concentrated in the central region(C3/C4-T7/T8). Compared with that before iTBS treatment(0.251(0.232, 0.299)), the PLI of α band increased after iTBS treatment(0.286(0.241, 0.359)), but the difference was not statistically significant( P>0.05). Conclusion:Single iTBS treatment can significantly increase the EEG functional connectivity in patients with MCI, indicating that iTBS targeting the left DLPFC can effectively regulate the EEG functional connectivity in patients with MCI, which may reveal the mechanism of iTBS in improving cognitive function in patients with MCI.
