Advances in neuroimaging studies of cerebral small vessel disease combined with depression
10.3760/cma.j.cn371468-20220212-00052
- VernacularTitle:脑小血管病伴发抑郁的神经影像学研究进展
- Author:
Jinbiao LI
1
;
Liqian CUI
;
Hao LI
;
Huixing ZENG
;
Yuhua FAN
Author Information
1. 中山大学附属第一医院神经科，广东省重大神经疾病诊治研究重点实验室，国家临床重点专科和国家重点学科，广州 510080
- Keywords:
Cerebral small vessel disease;
Depression;
Neuroimaging;
Neural circuit
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(8):758-763
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common psychiatric symptom in cerebral small vessel disease (CSVD), which has a certain relationship with impairment of cognitive function and can significantly increase the mortality and morbidity of CSVD patients. The occurrence of CVSD-associated depression is less related to psychological stress, but is associated with the impairment of the brain's emotional circuit. This article reviewed the correlation between the imaging features of CVSD and the occurrence and development of depression in recent years, and the neuroimaging mechanism of depression associated with CVSD. Many literatures have shown that deep white matter hyperintensities and asymptomatic lacunar infarction in the basal ganglia are independent risk factors for depression in CSVD, and the reduction of local brain volume is associated with depression. The neuroimaging mechanism of depression associated with CSVD suggests that the occurrence of depressive symptoms is related to the neural circuits in the lobar cortex-subcortical limbic area. These findings provide clues for exploring the neuropathological mechanisms and specific treatment methods of depression associated with CVSD.
