Functional connectivity analysis of sensory motor network in patients with bipolar disorder type Ⅰ
10.3760/cma.j.cn371468-20220112-00015
- VernacularTitle:双相情感障碍Ⅰ型患者大脑感觉运动网络功能连接分析
- Author:
Wenjing ZHU
1
;
Zhiyu CHEN
;
Wenxin TANG
;
Cheng ZHU
;
Yan LIANG
;
Yonghui SHEN
;
Fengfeng XUE
;
Ziming XU
Author Information
1. 浙江大学医学院附属精神卫生中心 杭州市第七人民医院精神科，杭州 310013
- Keywords:
Bipolar disorder;
Resting state functional magnetic resonance imaging;
Independent component analysis;
Resting state brain network;
Sensory motor network
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(8):692-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the functional connectivity (FC) characteristics of sensory motor network (SMN) in patients with bipolar disorder type Ⅰ (BD-Ⅰ) by independent component analysis (ICA), and explore the correlation between abnormal SMN and clinical symptoms.Methods:Eighteen patients with BD-Ⅰ (BD-Ⅰ group) and 20 matched normal controls (HC group) were included.Both groups received resting state fMRI (rs-fMRI) scanning.Based on ICA-fMRI data, one-sample t-test and two-sample t-test were used to analyze the components of SMN and to explore abnormal brain regions between the two groups.Functional network analysis (FNC) was also used to explore the functional connectivity between SMN and other brain networks.Pearson correlation analysis were conducted by SPSS 17.0 to measure the potential associations between intra-and inter-network functional connectivity and age, education, score of Bech-Rafaelsen mania rating scale (BRMS), score of positive and negative syndrome scale (PANSS) and other indicators. Results:In BD-Ⅰ group, the functional connection in the right paracentral lobule (MIN: x=8, y=-32, z=68, t=4.86, P<0.001) and the right postcentral gyrus (MIN: x=41, y=-26, z=53, t=3.33, P<0.001) in SMN were higher than those in HC group.Compared with HC group, the connectivity value in patients with BD-Ⅰ increased between SMN-DAN (0.247±0.073, -0.078±0.080, t=-2.974, P<0.01, FDR adjusted), while the connectivity value decreased between SMN-DMN(-0.037±0.054, 0.272±0.067, t=3.520, P<0.01, FDR adjusted) and between SMN-rFPN(-0.034±0.055, 0.231±0.070, t=2.939, P<0.01, FDR adjusted). Conclusion:The sensorimotor network of patients with BD-Ⅰ has abnormal functional connections within and between networks, and FC values in some networks are positively correlated with manic symptoms, which may be part of the neural mechanisms of patients with BD-Ⅰ.
