Changes of brain oxygenated hemoglobin concentration in adolescent patients with depression under speech fluency task
10.3760/cma.j.cn371468-20220305-00093
- VernacularTitle:青少年抑郁患者在言语流畅性任务下脑氧合血红蛋白水平的变化
- Author:
Aobo CHENG
1
;
Jiaqi FAN
;
Lihui LIU
;
Jinning LIU
;
Lili ZHANG
;
Hongying WANG
;
Yunshu ZHANG
;
Jianli YANG
;
Keqing LI
Author Information
1. 开滦精神卫生中心中西医病区，唐山 063000
- Keywords:
Functional near-infrared spectroscopy;
Verbal fluency test;
Adolescent depression;
Cognitive function;
Oxygenated hemoglobin
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(7):629-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics and differences of oxygenated hemoglobin responses in different brain regions in adolescent depressive disorder patients and healthy adolescents during speech fluency task based on functional near-infrared spectroscopy imaging.Methods:From March 2021 to June 2021, twenty-nine adolescents with depression(depressed group) and 26 healthy adolescents(normal group) were enrolled. The severity of depression was assessed by Hamilton depression scale, and the speech fluency task was performed by functional near-infrared spectroscopy brain imaging, and the relative concentrations of oxyhemoglobin in the prefrontal and bilateral temporal lobes were measured.SPSS 26.0 statistical software was used for data analysis, chi-square test was used for gender count data. The t-test was used for comparison of two groups. The measurement data that did not conform to normal distribution were compared between the two groups by Mann-Whitney U test. Results:In the speech fluency task, there was no significant difference in the concentration of oxygenated hemoglobin in prefrontal and left temporal between the depressed group and the normal group (both P>0.05); the oxygenated hemoglobin concentration in the right temporal lobe(-9.179(-22.231, 4.789)) of depressed group was significantly lower than that of the normal group (12.754(-9.438, 35.008)), and the difference was statistically significant ( U=538.00, P<0.05). The oxygenated hemoglobin concentration in right temporal lobe of depressed group had no correlation with the score of Hamilton depression rating scale ( r=0.092, P>0.05). Conclusion:The right temporal lobe function of adolescent depression patients is lower than that of healthy controls during speech fluency tasks, which provides a basis for study of the relationship between depression and some cognitive sensitivity impairment and the function of right temporal lobe.
