Research progress in imaging genetics of obsessive-compulsive disorder
10.3760/cma.j.cn371468-20211007-00569
- VernacularTitle:强迫障碍的影像遗传学研究进展
- Author:
Xiaodan LU
1
;
Shuming ZHONG
;
Hui ZHAO
;
Yiliang ZHANG
;
Kaiwei YE
;
Yanbin JIA
Author Information
1. 暨南大学附属第一医院精神医学科，广州 510630
- Keywords:
Obsessive-compulsive disorder;
Imaging genetics;
Genetic variation;
Genes
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(6):571-576
- CountryChina
- Language:Chinese
-
Abstract:
Obsessive-compulsive disorder (OCD) mainly manifests as obsessions and compulsions with the characteristics of early age of onset, long illness duration, and low diagnosis and treatment rate.The development of OCD involves mutations in genes associated with the 5-hydroxytryptamine, glutamate, and dopamine systems, as well as changes in the brain structure and function.However, how the potentially pathogenic genes affect brain structure and function and lead to different clinical manifestations remains unknown.Imaging genetics has been used to study the etiological mechanisms of OCD by combining genetics and imaging to analyze the relationship between genetic variation, neurologic and clinical manifestations.As a complex polygenic disease, imaging genetics that combines polygenic association analysis with epigenetic inheritance may become a new trend and perspective to explore the mechanism of the environment-gene-brain-behavior model in OCD.Therefore, this paper reviewed the related imaging genetics studies of OCD, and provided a theoretical basis for the etiological mechanism and precise intervention for OCD.
