Research progress on the mechanism of ferroptosis in septic cardiomyopathy
10.3760/cma.j.cn121430-20220823-00776
- VernacularTitle:铁死亡在脓毒性心肌病中的作用机制研究进展
- Author:
Jiayu SONG
1
;
Yiming HE
;
Kaixuan ZHOU
;
Jiabao XUE
;
Xue ZI
;
Lijing LI
Author Information
1. 长春中医药大学药学院，吉林长春 130117
- Keywords:
Sepsis;
Septic cardiomyopathy;
Mitochondrial dysfunction;
Ferroptosis
- From:
Chinese Critical Care Medicine
2022;34(10):1107-1111
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a serious complication of infection, and its further development may lead to multi-organ dysfunction syndrome. Sepsis cardiomyopathy is a common complication of sepsis and has been directly linked to high mortality. Although the pathogenesis of septic cardiomyopathy is not fully understood, in-depth study of the pathogenesis of septic cardiomyopathy and the identification of its potential therapeutic targets may reduce mortality in patients with sepsis. Ferroptosis is an iron-dependent mode of cell death that has been shown to be involved in the pathophysiological mechanisms of many diseases. Some related studies have reported that ferroptosis may be a potential mechanism of septic cardiomyopathy. This review provides new insights into the mechanisms of mitochondrial dysfunction, lipid peroxidation, xc-system, glutathione peroxidase 4 (GPX4), iron metabolism and the role of ferroptosiswith septic cardiomyopathy for further research and treatment of septic cardiomyopathy.
